For the condition (ii) neurons within a given minicolumn are stereotypically interconnected in the vertical dimension, which prevents repeated triggering SSEs and ensures signal parallel propagation columnar segregation avoids incorrect synaptic connections between adjacent columns and signal propagation across layers overwhelmingly prefers columnar direction. Evidence supporting an effective SSCCPI circuit includes that for the condition, (i) time delay enhances SSEs, suggesting that response latency induces SSEs in high-intensity stimuli irregular firing causes asynchronous SSEs asynchronous SSEs relate to healthy neurons and rigorous SSEs relate to brain disorders. We introduce a multithreshold decoder to correct encoding errors. We encode the membrane potential responses to stimuli using the non-linear autoregressive integrated process derived by applying Newton's second law to stochastic resilience systems. We derive the sufficient conditions for an effective (fast, reliable, and precise) SSCCPI circuit: (i) SSEs are asynchronous (near synchronous) (ii) cortical columns prevent both repeatedly triggering SSEs and incorrectly synaptic connections between adjacent columns and (iii) the propagator in interneurons is temporally complete fidelity and reliable. We hypothesize that when a high-intensity thalamic input triggers synchronous spike events (SSEs), dense spikes are scattered to many receiving neurons within a cortical column in layer IV, many sparse spike trains are propagated in parallel along minicolumns at a substantially high speed and finally integrated into an output spike train toward or in layer Va. Here we propose a SSCCPI circuit to address this issue. The mechanisms underlying an effective propagation of high intensity information over a background of irregular firing and response latency in cognitive processes remain unclear. Faculty of Management and Economics, Kaetsu University, Tokyo, Japan.
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